양대혁 조교수
YANG, Dae Hyeok
- 02-2164-4965
- yangdh@catholic.ac.kr
- 다솔관 D242
연구분야
의약품 및 의료기기 기반 고기능성 바이오 소재
연구키워드
첨단 바이오 소재 제조
주사제형/패치형 약물 전달
융복합 의료기기
교수소개
고기능성 바이오 소재를 기반으로 의약품과 의료기기를 아우르는 융합형 플랫폼 기술을 개발하여 실질적인 임상적 가치를 창출하는 것을 목표로 합니다. 특히, 고분자 나노입자, 하이드로젤 기반의 첨단 의료 소재를 설계하고, 약물전달시스템(DDS), 재생의료, 정밀치료 응용까지 확장 가능한 플랫폼 기술로의 개발을 목표로 하고 있습니다. 기초 소재 설계에서 전임상 검증, 기술이전 및 사업화에 이르는 전주기 연구 체계를 구축하여, 미래 의료 패러다임을 선도하는 글로벌 연구 거점으로 도약하고자 합니다.
Our goal is to create practical clinical value by developing convergent platform technologies that encompass pharmaceuticals and medical devices based on highly functional biomaterials. In particular, we focus on designing advanced medical materials based on polymers, nanomaterials, and hydrogels, aiming to develop them into scalable platform technologies for applications in Drug Delivery Systems (DDS), regenerative medicine, and precision therapy. By establishing a full-cycle research system from basic material design to preclinical validation, technology transfer, and commercialization, we aspire to become a global research hub leading the future medical paradigm.
최종학력
2010.03.24 | 일본과학기술원 | 재료과학 | 공학박사
연구실적
-
2026.09
| 교신저자
| MICROCHEMICAL JOURNAL, 제228권 1호, pp.119146-119155
Construction of electrochemical Interleukin-6 biosensor composed of antibody/quantum dot heterolayer for rapid chronic disease detection -
2026.08
| 교신저자
| MATERIALS TODAY ADVANCES, 제31권 1호, pp.100901-100915
Adhesion molecules-targeted membrane vesicle coatings restore vascular integrity in cardiovascular implants -
2026.07
| 공동저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 제23권 5호, pp.639-651
Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation -
2026.07
| 공동저자
| BIOMATERIALS RESEARCH, 제30권 1호, pp.0391-0391
Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration -
2026.06
| 교신저자
| MATERIALS TODAY BIO, 제38권 1호, pp.103311-103311
Locally injectable visible light-cured carboxymethyl chitosan hydrogels with indocyanine green-methyl-β-cyclodextrin for breast cancer phototherapy -
2026.06
| 교신저자
| PROGRESS IN MATERIALS SCIENCE, 제160권
Polymer modified cyclodextrin-based polyrotaxanes: From functionalization to applications -
2026.06
| 공동저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 제23권 4호, pp.537-550
Rapid and Efficient Combined Decellularization with Physical, Chemical and Enzymatic Treatment for Production of Bovine-Derived Meniscal Implant to Replace Damaged Meniscus -
2026.05
| 교신저자
| SMALL STRUCTURES, 제7권 5호, pp.70437-70448
Fabrication of Transparent Microneedle Patch for Minimally Invasive Glucose Monitoring Optical Biosensor -
2026.03
| 교신저자
| INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 제349권
A mechanically tunable photo-cured hydrogel system based on methacrylated collagen-keratin inter-penetrating networks for rapid and enhanced wound healing -
2026.02
| 제1저자
| CARBOHYDRATE POLYMERS, 제373권 1호, pp.124571-124571
Sprayable, crosslinker-free, and in situ-forming Schiff-based hydrogels based on oxidized sodium alginate and carbohydrazide-modified gelatin for rapid hemostasis -
2025.12
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제152권 1호, pp.411-422
Investigation on biomimetic mineralization and its effect on MG-63 cell behavior on poly L-lactic acid surfaces through poly (2-methacryloyloxyethyl phosphorylcholine) conjugation -
2025.12
| 공동저자
| MATERIALS TODAY BIO, 제35권 1호, pp.102274-102274
Recent advances in applications of nanoparticles and decellularized ECM for organoid engineering -
2025.11
| 교신저자
| JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 제272권 1호, pp.113281-113281
Synthesis and characterizations of lysosome-targeting morpholine-porphyrin fluorescent probes -
2025.06
| 교신저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 제22권 4호, pp.515-526
Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Dressing for Accelerated Wound Healing -
2025.05
| 교신저자
| MACROMOLECULAR RESEARCH, 제33권 5호, pp.655-665
FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression -
2024.12
| 교신저자
| DYES AND PIGMENTS, 제231권 1호, pp.112369-112369
Porphyrin-based fluorescent probes for imaging mitochondria in living cells -
2024.12
| 교신저자
| BIOACTIVE MATERIALS, 제42권 1호, pp.207-225
Versatile effects of galectin-1 protein-containing lipid bilayer coating for cardiovascular applications -
2024.06
| 제1저자
| MATERIALS TODAY BIO, 제26권 2024호, pp.101016-101016
A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications -
2024.04
| 공동저자
| JOURNAL OF CONTROLLED RELEASE, 제368권 1호, pp.453-465
Fibroblast function recovery through rejuvenation effect of nanovesicles extracted from human adipose-derived stem cells irradiated with red light -
2024.03
| 공동저자
| INFOMAT, 제6권 3호, pp.12489-12489
Inhibiting scar formation via wearable multilayer stacked electret patch: Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction -
2023.11
| 제1저자
| ACS OMEGA, 제8권 46호, pp.44076-44085
Development of a Temperature-Responsive Hydrogel Incorporating PVA into NIPAAm for Controllable Drug Release in Skin Regeneration -
2023.07
| 공동저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE (조직공학과 재생의학), 제20권 4호, pp.553-562
Three-Dimensional Cell Culture System for Tendon Tissue Engineering -
2023.07
| 제1저자
| CARBOHYDRATE POLYMERS, 제311권 0호, pp.120620-120620
Visible light-curable methacrylated glycol chitosan hydrogel patches for prenatal closure of fetal myelomeningocele -
2023.07
| 교신저자
| APPLIED SURFACE SCIENCE, 제624권, pp.156424-156424
Neural interfacing biomaterials coated with the firmly tethered neuro-specific lipid bilayer -
2023.03
| 교신저자
| MACROMOLECULAR RESEARCH, 제31권 3호, pp.257-270
Biodegradable sponges based on starch, hyaluronic acid, and poly-L-lysine as potent hemostatic agents -
2023.02
| 교신저자
| INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 제227권 0호, pp.641-653
Guided cortical and cancellous bone formation using a minimally invasive technique of BMSC- and BMP-2-laden visible light-cured carboxymethyl chitosan hydrogels -
2023.02
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제118권, pp.101-108
Effect of thrombin conjugation on hemostatic efficacy of PLGA mesh through reagent free surface modification -
2023.01
| 제1저자
| NPJ REGENERATIVE MEDICINE, 제8권 1호, pp.2-2
In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration -
2022.12
| 공동저자
| 생체재료학회지(BIOMATERIALS RESEARCH), 제26권 1호, pp.79-79
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration -
2022.07
| 제1저자
| CARBOHYDRATE POLYMERS, 제287권 0호, pp.119328-119328
3D printing of cell-laden visible light curable glycol chitosan bioink for bone tissue engineering -
2022.04
| 공동저자
| MACROMOLECULAR RESEARCH, 제30권 4호, pp.223-229
Mechanical and Cell-Adhesive Properties of Gelatin/Polyvinyl Alcohol Hydrogels and Their Application in Wound Dressing -
2021.10
| 교신저자
| POLYMERS, 제13권 19호, pp.3279-3279
Preparation of Foam Dressings Based on Gelatin, Hyaluronic Acid, and Carboxymethyl Chitosan Containing Fibroblast Growth Factor-7 for Dermal Regeneration -
2021.08
| 공동저자
| SURFACES AND INTERFACES, 제25권 0호, pp.101280-101280
Anti-thrombotic polymer surfaces modified with zwitterionic and fluorinated surface-migrating oligomers -
2021.07
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제99권 0호, pp.204-213
Cyclic RGDfK- and Sulfo-Cy5.5-functionalized mPEG-PCL theranostic nanosystems for hepatocellular carcinoma -
2021.05
| 교신저자
| MATERIALS, 제14권 9호, pp.2270-2270
Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing -
2021.05
| 공동저자
| BIOMATERIALS SCIENCE, 제9권 10호, pp.3750-3761
Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma -
2021.02
| 교신저자
| NANOMATERIALS, 제11권 2호, pp.317-317
Injectable Glycol Chitosan Hydrogel Containing Folic Acid-Functionalized Cyclodextrin-Paclitaxel Complex for Breast Cancer Therapy -
2021.01
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제22권 2호, pp.700-700
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive -
2020.12
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제92권 0호, pp.158-166
In vivo imaging of reactive oxygen species (ROS)-producing pro-inflammatory macrophages in murine carotid atheromas using a CD44-targetable and ROS-responsive nanosensor -
2020.09
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제89권 0호, pp.470-475
Preparation of a photocured GelMA hydrogel co-cultured with HOKs and HGFs for an artificial oral mucosal tissue model -
2020.08
| 공동저자
| BIOMATERIALS SCIENCE, 제8권 15호, pp.4334-4345
Injectable hydrogels based on MPEG-PCL-RGD and BMSCs for bone tissue engineering -
2020.04
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제84권 0호, pp.226-235
Preparation of novel RGD-conjugated thermosensitive mPEG-PCL composite hydrogels and in vitro investigation of their impacts on adhesion-dependent cellular behavior -
2020.02
| 공동저자
| PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 제37권 2호, pp.1900490-1900490
Multivalent Sorbitol Probes for Near-Infrared Photothermal Cancer Therapy -
2020.01
| 제1저자
| ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 제1249권, pp.85-93
Visible Light-Curable Hydrogel Systems for Tissue Engineering and Drug Delivery -
2020.01
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제81권 0호, pp.178-184
Optimization of cRGDfK ligand concentration on polymeric nanoparticles to maximize cancer targeting -
2019.11
| 교신저자
| NANOMATERIALS, 제9권 12호, pp.1652-1652
Doxorubicin·Hydrochloride/Cisplatin-Loaded Hydrogel/Nanosized (2-Hydroxypropyl)-Beta-Cyclodextrin Local Drug-Delivery System for Osteosarcoma Treatment In Vivo -
2019.10
| 교신저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제20권 19호, pp.4671-4671
Hydrogel-Mediated DOX·HCl/PTX Delivery System for Breast Cancer Therapy -
2019.09
| 공동저자
| CANCERS, 제11권 9호, pp.1286-1286
Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy -
2019.03
| 공동저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제71권 0호, pp.369-377
Preparation and anticancer activity evaluation of self-assembled paclitaxel conjugated MPEG-PCL micelles on 4T1 cells -
2019.02
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제70권 0호, pp.145-151
Engineered beta-cyclodextrin-based carrier for targeted doxorubicin delivery in breast cancer therapy in vivo -
2019.01
| 교신저자
| MARINE DRUGS, 제17권 1호, pp.41-41
Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery -
2019.01
| 교신저자
| MARINE DRUGS, 제17권 1호, pp.51-51
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw -
2018.11
| 교신저자
| DRUG DELIVERY, 제25권 1호, pp.1664-1671
A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin·hydrochloride for thyroid cancer treatment in vitro and in vivo -
2018.11
| 교신저자
| ARTIFICIAL CELLS, NANOMEDICINE AND BIOTECHNOLOGY, 제46권 sup2호, pp.874-882
Injectable visible light-cured glycol chitosan hydrogels with controlled release of anticancer drugs for local cancer therapy in vivo: a feasible study -
2018.11
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제67권 0호, pp.365-372
Visible light-cured glycol chitosan hydrogel dressing containing endothelial growth factor and basic fibroblast growth factor accelerates wound healing in vivo -
2018.11
| 제1저자
| DRUG DELIVERY, 제25권 1호, pp.950-960
Preparation of poly-L-lysine-based nanoparticles with pH-sensitive release of curcumin for targeted imaging and therapy of liver cancer in vitro and in vivo -
2018.10
| 교신저자
| MARINE DRUGS, 제16권 10호, pp.351-351
The Cocktail Effect of BMP-2 and TGF-β1 Loaded in Visible Light-Cured Glycol Chitosan Hydrogels for the Enhancement of Bone Formation in a Rat Tibial Defect Model -
2018.10
| 공동저자
| ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 제1077권 0호, pp.475-485
Chitosan for Tissue Engineering -
2018.01
| 교신저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제57권 0호, pp.37-44
Supramolecular assembly based on host-guest interaction between beta-cyclodextrin and adamantane for specifically targeted cancer imaging -
2017.11
| 공동저자
| JOURNAL OF MATERIALS CHEMISTRY B, 제5권 44호, pp.8725-8737
Advanced capability of radially aligned fibrous scaffolds coated with polydopamine for guiding directional migration of human mesenchymal stem cells -
2017.09
| 교신저자
| MOLECULES, 제22권 9호, pp.1513-1513
Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo -
2017.09
| 제1저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제53권 0호, pp.360-370
Preparation and evaluation of visible-light cured glycol chitosan hydrogel dressing containing dual growth factors for accelerated wound healing -
2017.08
| 제1저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 8호, pp.1695-1695
Preparation and Evaluation of Dexamethasone (DEX)/Growth and Differentiation Factor-5 (GDF-5) Surface-Modified Titanium Using -Cyclodextrin-Conjugated Heparin (CD-Hep) for Enhanced Osteogenic Activity In Vitro and In Vivo -
2017.08
| 공동저자
| ONCOTARGET, 제8권 39호, pp.65770-65777
Real-time in vivo imaging of metastatic bone tumors with a targeted near-infrared fluorophore -
2017.07
| 공동저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 7호, pp.1462-1462
Effects of Titanium Mesh Surfaces-Coated with Hydroxyapatite/beta-Tricalcium Phosphate Nanotubes on Acetabular Bone Defects in Rabbits -
2017.05
| 제1저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제49권 0호, pp.158-167
Surface modification of titanium with β-CD/polydopamine for a controlled release of lovastatin, and its effect on the enhanced osteogenic activity -
2017.01
| 제1저자
| JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 제45권 0호, pp.156-163
Preparation of redox-sensitive β-CD-based nanoparticles with controlled release of curcumin for improved therapeutic effect on liver cancer in vitro -
2017.01
| 제1저자
| INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 제18권 1호, pp.229-229
Surface modification of titanium with BMP-2/GDF-5 by a heparin linker and its efficacy as a dental implant -
2016.01
| 제1저자
| JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 제16권 1호, pp.280-286
In Vitro Osteogenic Differentiation Enhanced by Zirconia Coated with Nano-Layered Growth and Differentiation Factor-5 -
2015.09
| 제1저자
| JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 제9권 9호, pp.1067-1077
Surface modification of titanium with hydroxyapatite-heparin-BMP-2 enhances the efficacy of bone formation and osseointegration in vitro and in vivo -
2015.07
| 공동저자
| JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 제9권 7호, pp.819-825
Cellular behaviour of hepatocyte-like cells from nude mouse bone marrow-derived mesenchymal stem cells on galactosylated poly(D,L-lactic-co-glycolic acid) -
2015.06
| 제1저자
| JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 제11권 6호, pp.1007-1015
A Titanium Surface-Modified with Nano-Sized Hydroxyapatite and Simvastatin Enhances Bone Formation and Osseointegration -
2015.01
| 제1저자
| INTERNATIONAL JOURNAL OF TISSUE REGENERATION, 제6권 1호, pp.1-8
preparation methods of biodegraderble supramolecular hydrogels based on a-cyclodextrin and biodegraderble polyester polymers for pharmaceutical and biomedical applications -
2014.12
| 교신저자
| MARINE DRUGS, 제12권 12호, pp.6038-6057
Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy -
2014.04
| 제1저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학), 제11권 2호, pp.163-170
Local delivery of recombinant human bone morphogenic protein-2 (rhBMP-2) from rhBMP-2/heparin complex fixed to a chitosan scaffold enhances osteoblast behavior -
2013.10
| 공동저자
| CARBOHYDRATE POLYMERS, 제98권 1호, pp.546-554
The effect of titanium with heparin/BMP-2 complex for improving osteoblast activity -
2013.08
| 제1저자
| MACROMOLECULAR RESEARCH, 제21권 8호, pp.931-939
Evaluations of chitosan/poly(D,L-lactic-co-glycolic acid) composite fibrous scaffold for tissue engineering applications -
2013.03
| 제1저자
| JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 제9권 3호, pp.511-515
Burn-Wound Healing Effect of Gelatin/Polyurethane Nanofiber Scaffold Containing Silver-Sulfadiazine -
2013.03
| 공동저자
| JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 제9권 3호, pp.424-429
Poly(L-lactic acid)/Hydroxyapatite Nanocylinders as Nanofibrous Structure for Bone Tissue Engineering Scaffolds -
2013.01
| 공동저자
| CARBOHYDRATE POLYMERS, 제92권 1호, pp.167-175
ZrO2 surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry -
2012.07
| 제1저자
| MACROMOLECULAR RESEARCH, 제20권 7호, pp.754-761
In vitro evaluation of simvastatin acid (SVA) coated beta-tricalcium phosphate (beta-TCP) particle on bone tissue regeneration -
2012.06
| 공동저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학), 제9권 3호, pp.128-136
Specific temporal culturing and microgroove depth influence osteoblast differentiation of human periodontal ligament cells grown on titanium substrata -
2012.06
| 제1저자
| MACROMOLECULAR RESEARCH, 제20권 6호, pp.627-633
Evaluation of genesis-BCPTM scaffold composed of hydroxyapatite and β-tricalcium phosphate on bone formation -
2012.04
| 공동저자
| TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학), 제9권 2호, pp.75-83
Differentially Expressed Genes in Human Gingival Fibroblasts Cultured on Microgrooved Titanium Substrata: A Pilot Study -
2012.01
| 제1저자
| BIOMATERIALS, 제33권 3호, pp.856-866
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
-
2018.01
| 공동
| 군자출판사
재생의학. Vol.1
-
2020.11.17
| 공동발명자
| 가톨릭대학교 산학협력단
가시광선 광경화 수용성 키토산 유도체, 키토산 하이드로겔 및 이의 제조방법 -
2020.08.10
| 공동발명자
| 가톨릭대학교 산학협력단
지혈가능 트롬빈 결합 생분해성 PLGA 메쉬 및 이의 제조방법(Hemostatic-capable thrombin-binding biodegradable PLGA mesh and method for manufacturing thereof) -
2019.03.12
| 공동발명자
| 가톨릭대학교 산학협력단
온도감응성 생분해 하이드로겔 -
2018.07.18
| 공동발명자
| 가톨릭대학교 산학협력단
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